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Autoantibodies also have the probable to cause interference in troponin immunometric assay techniques. Bogus-good or Phony-negative values may well occur, based on if the autoantibody-analyte complex partitions into your no cost or maybe the bound analyte portion.
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[59] 2nd, calculated assay concentrations fail to generally be consistent because cTnI circulates in many sorts; the antibodies Utilized in the available assays recognize diverse epitopes of cTnI even for assays and instruments promoted by a similar manufacturer.[60]
Elevated troponin concentrations can arise on account of both cardiac and noncardiac conditions. Probable leads to incorporate:
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One stimulus that is definitely more and more accountable for HAMA generation is mouse monoclonal antibodies Utilized in diagnostic impression analysis and immune-directed therapy.
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